Royal Air Force Typhoon FGR4s have joined forces with French aircraft in a joint strike targeting an underground arms cache in Syrian territory employed by the IS group, as stated by the British defence ministry.
The facility, located using reconnaissance, was believed to be storing arms and explosives, the statement said, and was positioned in mountainous terrain just to the north of Palmyra in the heart of Syria.
"Our aircraft used laser-guided Paveway IV weapons to hit a several access tunnels down to the site... early reports are that the target was engaged successfully," the MoD said.
There was no evidence of any civilian impact in the operation conducted Saturday night and each participating jet returned to base without incident, the ministry further stated.
The British jets were backed up by a Voyager tanker plane.
IS - also known as ISIS - established jihadist rule over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This operation demonstrates the UK's leading role, and resolve to stand shoulder to shoulder with our allies, to eradicate any resurgence of IS and their harmful and extremist ideologies in the region," UK Defence Secretary the minister remarked.
RAF aircraft have conducted overwatch operations over Syrian airspace to "prevent any attempted comeback" of Islamic State following its defeat at the battle of Baghuz in 2019, the MoD reported.
"I must thank the personnel of the UK armed forces participating in this mission for their professionalism and their bravery," he added. "They were among thousands of British personnel on duty over the festive period. This operation, to remove terrorist threats who threaten our way of life, shows how our armed forces are prepared to act, continuously, protecting the UK within its borders and influential overseas."
In December, the US military executed what it termed a "large-scale strike" on Islamic State objectives in the country, following an ambush resulted in the deaths of two US troops and a local interpreter in Palmyra.
The United Nations says Daesh still boasts roughly 5-7 thousand fighters in both countries.